Mother in the Middle

Mother in the Middle

A Biologist's Story of Caring for Parent and Child

By Sybil Lockhart

Touchstone Books, Hardcover, 9781416541554, 310pp.

Publication Date: February 2009


Sybil Lockhart, a Berkeley neurobiologist, became a "mother in the middle" when she was pregnant with her second daughter and her mother was diagnosed with Alzheimer's disease. What makes Sybil's story different, and so powerful, is that she understood the neurological processes, by turns exciting and devastating, that were taking place in the brains of those she loved. Interweaving her scientific expertise with her own complicated emotions, she writes with elegant simplicity and breathtaking honesty about biology's inevitable, powerful effects on the people around her.

When her mother begins to show the first subtle signs of the disease that is slowly ravaging her brain, Sybil refuses to consider the possibility of dementia, insisting that all her mother needs is a daughter nearby. She relocates her young family to her beloved San Francisco Bay Area, where her memories of her mother and her childhood are deeply anchored. As Sybil sets about creating new memories against the backdrop of her past, the emerging undeniable truth about her mother's condition threatens to overwhelm her ability to maintain her career, nurture her marriage, raise her young daughter, and care for herself during her second pregnancy. Even though she appreciates the beauty of the dramatic biological processes at work inside the brains of her family members, she also understands their inevitable power, and she bravely describes the complicated emotions -- denial, rage, ambivalence, exhaustion -- that so many caregivers experience.

With a unique combination of science and intimate experience, Mother in the Middle is a story of mothers and daughters, science and creativity, and life's exquisite intertwining of love and loss.

About the Author
Sybil Lockart was a biologist at UC Berkeley before quitting her job to become a full time mother and caregiver. She writes a popular column called "Mama in the Middle" for Literary Mama Magazine ( She lives in Berkeley, California with her husband and two daughters.

Praise For Mother in the Middle

"Mother in the Middle is a caregiver's journey told from the most unique vantage point. As a neurobiologist, Sybil Lockhart reveals a fascinating view into an Alzheimer's we normally can't see -- into the very molecules and neurons gone haywire inside her mother's brain. As a daughter, Lockhart reveals her mother's Alzheimer's as she sees and feels it with unflinching honesty, empathy, and love. It is a story about losing a mother and becoming a mother, about a mother's mind, told from a daughter's heart." -- Lisa Genova, author of Still Alice

"Sybil Lockhart's insights as a neurobiologist and a daughter watching her mother disintegrate from dementia are meaningful and poignant -- and her writing about mothering her own daughters equally so. In the midst of the pain are uplifting lessons and a new map for living with the illness of a loved one." -- Richard M. Cohen, New York Times bestselling author of Blindsided and Strong at the Broken Places