The Easy Chair Coffee Shop
Run by dedicated baristas and bookstore aficionados (and a member of the Roaster's Guild), serves deli foods and pastries as well as many coffee drinks, has outdoor tables, a sociable cafe near the bar, and a quieter, studious area in a side room with many books still for sale (but sadly no longer a bookstore).
UPDATE: Used books are here! We put the call out for donations. Blacksburg currently does not have a used bookstore other than the YMCA which holds back most of its inventory for book fairs. (We support the Y, but we need a place people can browse daily for great reads.) Bring us your used books to trade for coffee drinks. Good, new, current trade paperbacks and hardcovers only. No textbooks please!